Destrehan is a Census Designated Place in St. Charles Parish along the Mississippi River. The community is named after Jean Noël Destréhan (1754–1823), who was twice President of the Orleans Territory’s legislative council during his service there in 1806 and 1811. He was elected to the United States Senate when Louisiana became a state in 1812, but he resigned after a month.

Jean Noël lived in what is now called Destrehan Plantation, which is listed on the National Register of Historic Places. The main house has been restored and is one of the attractions on the Great River Road along the Mississippi River.

The two sides of the river in St. Charles Parish are now connected by a bridge, but were once spanned only by a ferry. A tragic accident occurred on one of these ferries in 1976, when a tanker rammed into the ferry and sent it’s passengers into the water. Seventy eight passengers and crew died.

Destrehan is served by the St. Charles Parish public school system, which has one high school, one middle school and two elementary schools in Destrehan.